Anti-CREB/CREB1 Antibody Picoband®

About this product

Boster Bio Anti-CREB/CREB1 Antibody Picoband® catalog # PB9100. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9100

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

CREB1, also known as cAMP responsive element binding protein 1, is a protein that in humans is encoded by the CREB1 gene. It is mapped to 2q33.3. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription. This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.

Synonyms

Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1; CREB1

Gene Name

CREB1

Gene ID

12912

UniProt

P16220

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human CREB recombinant protein (Position: M1-T177) . Human CREB shares 99% and 98% amino acid (aa) sequences identity with mouse and rat CREB, respectively.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in placenta.

Applications

WB, Flow Cytometry

Field of Research

Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Transcription, Transcription Factors

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

References & Citations

1. Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (December 1988) . Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 242 (4884) : 1430–3. 2. Taylor AK, Klisak I, Mohandas T, Sparkes RS, Li C, Gaynor R, Lusis AJ (July 1990) . Assignment of the human gene for CREB1 to chromosome 2q32.3-q34. Genomics 7 (3) : 416–21.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

35 kDa

Observed Molecular Weight

43 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Cyclic AMP-responsive element-binding protein 1

Subcellular Location

Nucleus .

Sequence Similarities

Belongs to the bZIP family.

Protein Name

Cyclic AMP-responsive element-binding protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.