Anti-Glucose Transporter GLUT4/SLC2A4 Antibody Picoband®

About this product

Boster Bio Anti-Glucose Transporter GLUT4/SLC2A4 Antibody Picoband® catalog # PB9109. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9109

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

GLUT4, also known as SLC2A4 or solute carrier family 2 (facilitated glucose transporter) member 4, is a protein that in humans is encoded by the GLUT4 gene. It is mapped to 17p13.1. This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM) .

Synonyms

Solute carrier family 2, facilitated glucose transporter member 4; Glucose transporter type 4, insulin-responsive; GLUT-4; SLC2A4; GLUT4

Gene Name

SLC2A4

Gene ID

6517

UniProt

P14672

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human GLUT4 recombinant protein (Position: N333-D509) . Human GLUT4 shares 97% amino acid (aa) sequence identity with mouse GLUT4.

Clonality

Polyclonal

Tissue Specificity

Skeletal and cardiac muscles; brown and white fat.

Applications

IHC, WB

Field of Research

Cardiovascular, Energy Metabolism, Energy Transfer Pathways, Epigenetics and Nuclear Signaling, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Transcription, Transcription Factors

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Insulin-regulated facilitative glucose transporter.

References & Citations

1. James DE, Brown R, Navarro J, Pilch PF (May 1988) . Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein. Nature 333 (6169) : 183–5. 2. James DE, Strube M, Mueckler M (March 1989) . Molecular cloning and characterization of an insulin-regulatable glucose transporter. Nature 338 (6210) : 83–7. 3. Birnbaum MJ (April 1989) . “Identification of a novel gene encoding an insulin-responsive glucose transporter protein”. Cell 57 (2) : 305–15.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

54787 MW

Observed Molecular Weight

55 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Solute carrier family 2, facilitated glucose transporter member 4

Subcellular Location

Cell membrane ; Multi-pass membrane protein . Endomembrane system ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.

Sequence Similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Protein Name

Solute carrier family 2, facilitated glucose transporter member 4

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.