Anti-SCP3/SYCP3 Antibody Picoband®

About this product

Boster Bio Anti-SCP3/SYCP3 Antibody catalog # RP1035. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

RP1035

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

SYCP3, also known as COR1 or SCP3, is a protein that in humans is encoded by the SYCP3 gene. It is mapped to 12q23.2. This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. SYCP3 has an essential meiotic function in human spermatogenesis that is compromised by the mutant protein by dominant-negative interference. SYCP3 is linked to inherited aneuploidy in female germ cells and provides a model system for studying age-dependent degeneration in oocytes.

Synonyms

Synaptonemal complex protein 3; SCP-3; SYCP3; SCP3

Gene Name

SYCP3

Gene ID

50511

UniProt

Q8IZU3

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human SCP3 recombinant protein (Position: E18-E223) . Human SCP3 shares 72% and 73% amino acid (aa) sequences identity with mouse and rat SCP3, respectively.

Clonality

Polyclonal

Tissue Specificity

Testis-specific. .

Applications

WB

Field of Research

Cell Biology, Cell Cycle, Cell Division, Chromosome Structure, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity) . .

References & Citations

1. Martinez-Garay I, Jablonka S, Sutajova M, Steuernagel P, Gal A, Kutsche K (Sep 2002) . A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region.Genomics 80 (3) : 259–67. 2. Mallon AM, Platzer M, Bate R, Gloeckner G, Botcherby MR, Nordsiek G, Strivens MA, Kioschis P, Dangel A, Cunningham D, Straw RN, Weston P, Gilbert M, Fernando S, Goodall K, Hunter G, Greystrong JS, Clarke D, Kimberley C, Goerdes M, Blechschmidt K, Rump A, Hinzmann B, Mundy CR, Miller W, Poustka A, Herman GE, Rhodes M, Denny P, Rosenthal A, Brown SD (Aug 2000) . Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. Genome Res 10 (6) : 758–75. 3. Miyamoto, T., Hasuike, S., Yogev, L., Maduro, M. R., Ishikawa, M., Westphal, H., Lamb, D. J. Azoospermia in patients heterozygous for a mutation in SYCP3. Lancet 362: 1714-1719, 2003.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

27729 MW

Observed Molecular Weight

28 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Synaptonemal complex protein 3

Subcellular Location

Nucleus . Chromosome . In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed. .

Protein Name

Synaptonemal complex protein 3

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.