Anti-Claudin 5/CLDN5 Antibody Picoband®

About this product

Boster Bio Anti-Claudin 5/CLDN5 Antibody catalog # RP1043. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

RP1043

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Claudin-5 (CLDN5) also known as BEC1, is a protein that in humans is encoded by the CLDN5 gene. By use of yeast artificial chromosomes, Claudin-5 is localized between polymorphic markers D22S944 and D22S941 on chromosome 22q11, both of which are deleted in more than 80% of VCFS patients. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. What's more, it plays a major role in tight junction-specific obliteration of the intercellular space.

Synonyms

Claudin-5; Transmembrane protein deleted in VCFS; TMDVCF; CLDN5; AWAL, TMVCF

Gene Name

CLDN5

Gene ID

7122

UniProt

O00501

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Claudin 5, different from the related mouse sequence by three amino acids and from the related rat sequence by four amino acids.

Clonality

Polyclonal

Applications

WB

Field of Research

Cell Adhesion, Cytoskeleton/ECM, Signal Transduction, Tight Junctions

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Plays a major role in tight junction-specific obliteration of the intercellular space. .

References & Citations

1. Sirotkin, H., Morrow, B., Saint-Jore, B., Puech, A., Das Gupta, R., Patanjali, S. R., Skoultchi, A., Weissman, S. M., Kucherlapati, R. Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome. 2. Peacock RE, Keen TJ, Inglehearn CF (Mar 1998) . Analysis of a human gene homologous to rat ventral prostate.1 protein. Genomics 46 (3) : 443–9. 3. Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

23147 MW

Observed Molecular Weight

23 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Claudin-5

Subcellular Location

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Protein Name

Claudin-5

Isotype

Rabbit IgG

Contents

243