Anti-GST3/GST pi/GSTP1 Antibody Picoband®

About this product

Boster Bio Anti-GST3/GST pi/GSTP1 Antibody Picoband® catalog # PB9184. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9184

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Glutathione S-transferases pi (GSTP1), also known as GST3, is an enzyme that in humans is encoded by the GSTP1 gene. This gene is mapped to 11q13.2. GSTP1 has 7 exons and 6 introns contained within approximately 2.8 kilobases. GSTP1 belongs to Glutathione S-transferases (GSTs) which are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. GSTP1 presents in all tissues and cells, with the exception of red cells, in which only erythrocyte GST (GSTe) is observed. What's more, GSTP1 is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

Synonyms

Glutathione S-transferase P;2.5.1.18; GST class-pi; GSTP1-1; GSTP1; FAEES3, GST3

Gene Name

GSTP1

Gene ID

2950

UniProt

P09211

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human GST3 recombinant protein (Position: P2-Q210) . Human GST3 shares 85% and 86% amino acid (aa) sequences identity with mouse and rat GST3, respectively.

Clonality

Polyclonal

Tissue Specificity

Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. .

Applications

Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Cancer, Cardiovascular, Metabolism, Mitochondrial Markers, Mitochondrial Metabolism, Neurogenesis, Neurology Process, Neuroscience, Oxidative Stress, Pathways and Processes, Redox Metabolism

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. .

References & Citations

1. Morrow, C. S.; Cowan, K. H.; Goldsmith, M. E. : Structure of the human genomic glutathione S-transferase-pi gene. Gene 75: 3-11, 1989. 2. Bora PS, Bora NS, Wu XL, Lange LG (Oct 1991) . Molecular cloning, sequencing, and expression of human myocardial fatty acid ethyl ester synthase-III cDNA. J Biol Chem 266 (25) : 16774–7. 3. Smith CM, Bora PS, Bora NS, Jones C, Gerhard DS (Nov 1995) . Genetic and radiation-reduced somatic cell hybrid sublocalization of the human GSTP1 gene. Cytogenet Cell Genet 71 (3) : 235–9.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

23356 MW

Observed Molecular Weight

23 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Glutathione S-transferase P

Subcellular Location

Cytoplasm . Mitochondrion . Nucleus . The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.

Sequence Similarities

Belongs to the GST superfamily. Pi family.

Protein Name

Glutathione S-transferase P

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.