Anti-Kv4.3/KCND3 Antibody Picoband®

About this product

Boster Bio Anti-Kv4.3/KCND3 Antibody Picoband® catalog # PB9229. Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9229

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Potassium voltage-gated channel subfamily D member 3, also known as Kv4.3, is a protein that in humans is encoded by the KCND3 gene. KCND3 is a member of the potassium channel, voltage-gated, shal-related subfamily. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. It is mapped to 1p13.2. KCND3 is important in membrane repolarization in excitable cells. It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.

Synonyms

Potassium voltage-gated channel subfamily D member 3; Voltage-gated potassium channel subunit Kv4.3; KCND3

Gene Name

KCND3

Gene ID

3752

UniProt

Q9UK17

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human Kv4.3 recombinant protein (Position: M1-H177) . Human Kv4.3 shares 100% and 99% amino acid (aa) sequences identity with mouse and rat Kv4.3, respectively.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas. .

Applications

WB

Field of Research

Cancer, Cancer Metabolism, Cardiovascular, Channels, Hypoxia, Immunology, Innate Immunity, Macrophage/Inflammation, Metabolism, Metabolism Processes, Pathways and Processes, Plasma Membrane, Response To Hypoxia, Signal Transduction, Vasculature

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I (To) current in heart and I (Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. .

References & Citations

1. Postma AV, Bezzina CR, de Vries JF, Wilde AA, Moorman AF, Mannens MM (Aug 2000) . Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3. Hum Genet 106 (6) : 614–9. 2. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005) . International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57 (4) : 473–508. 3. Entrez Gene: KCND3 potassium voltage-gated channel, Shal-related subfamily, member 3

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

73451 MW

Observed Molecular Weight

73 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Potassium voltage-gated channel subfamily D member 3

Subcellular Location

Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma . Cell projection, dendrite .

Sequence Similarities

Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily.

Protein Name

Potassium voltage-gated channel subfamily D member 3

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.