Anti-GDNF Receptor alpha 1/GFRA1 Antibody Picoband®

About this product

Boster Bio Anti-GDNF Receptor alpha 1/GFRA1 Antibody Picoband® catalog # PB9202. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9202

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor or GFRA1, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to chromosome 10q25.3. The protein encoded by this gene is a member of the GDNF receptor family. GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. It is a glycosylphosphatidylinositol (GPI) -linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is also a candidate gene for Hirschsprung disease. Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase.

Synonyms

GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1; GFRA1; GDNFRA, RETL1, TRNR1

Gene Name

GFRA1

Gene ID

14585

UniProt

P56159

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human GFRA1 recombinant protein (Position: D25-Q227) . Human GFRA1 shares 97% amino acid (aa) sequence identity with both mouse and rat GFRA1.

Clonality

Polyclonal

Tissue Specificity

T-cells and endothelial cells.

Applications

IHC, WB

Field of Research

Growth and Development, Neurology Process, Neuroscience

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) . .

References & Citations

1. Gorodinsky A, Zimonjic DB, Popescu NC, Milbrandt J (March 1998) . Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization. Cytogenet Cell Genet 78 (3-4) : 289–90. 2. Angrist M, Jing S, Bolk S, Bentley K, Nallasamy S, Halushka M, Fox GM, Chakravarti A (June 1998) . Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility. Genomics 48 (3) : 354–62. 3. Entrez Gene: GFRA1 GDNF family receptor alpha 1

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

51456 MW

Observed Molecular Weight

51 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

GDNF family receptor alpha-1

Subcellular Location

Cell membrane ; Lipid-anchor, GPI-anchor .

Sequence Similarities

Belongs to the glutamate--cysteine ligase type 3 family.

Protein Name

GDNF family receptor alpha-1

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.