Anti-IL16 Antibody Picoband®

About this product

Boster Bio Anti-IL16 Antibody Picoband® catalog # PB9238. Tested in ELISA, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9238

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin 16 (IL-16) is a cytokine that released by a variety of cells (including lymphocytes and some epithelial cells) that has been characterized as a chemoattractant for certain immune cells expressing the cell surface molecule CD4. It is mapped to 15q25.1. IL-16 was originally described as a factor that could attract activated T cells in humans. It was previously called lymphocyte chemoattractant factor (LCF), and the augmentation of IL16 stimulation by CCR5 plays a role in regulation of Th1 cell recruitment and activation at sites of inflammation.

Synonyms

Pro-interleukin-16; Interleukin-16; IL-16; Lymphocyte chemoattractant factor; LCF; IL16

Gene Name

IL16

Gene ID

3603

UniProt

Q14005

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human IL-16 recombinant protein (Position: S1212-S1332) . Human IL-16 shares 86% amino acid (aa) sequence identity with mouse IL-16.

Clonality

Polyclonal

Tissue Specificity

Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation.

Applications

ELISA, IHC, ICC, WB

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.

References & Citations

1. Cruikshank W, Center DM (1982) . Modulation of lymphocyte migration by human lymphokines. II. Purification of a lymphotactic factor (LCF) .J. Immunol. 128 (6) : 2569–74 2. Drwinga, H. L., Toji, L. H., Kim, C. H., Greene, A. E., Mulivor, R. A. NIGMS human/rodent somatic cell hybrid mapping panels 1 and 2. Genomics 16: 311-314, 1993. 3. Bannert, N., Kurth, R., Baier, M. The gene encoding mouse interleukin-16 consists of seven exons and maps to Chromosome 7 D2-D3. Immunogenetics 49: 704-706, 1999. 4. Hudson, T. J., Stein, L. D., Gerety, S. S., Ma, J., Castle, A. B., Silva, J., Slonim, D. K., Baptista, R., Kruglyak, L., Xu, S. H., Hu, X., Colbert, A. M. E., and 39 others. An STS-based map of the human genome. Science 270: 1945-1954, 1995.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

141752 MW

Observed Molecular Weight

45-55 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Pro-interleukin-16

Subcellular Location

Interleukin-16: Secreted.

Sequence Similarities

Contains 4 PDZ (DHR) domains.

Protein Name

Pro-interleukin-16

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.