Anti-IL15 Antibody Picoband®

About this product

Boster Bio Anti-IL15 Antibody Picoband® catalog # PB9244. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9244

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin (IL) -15 is a cytokine with the ability to stimulate the proliferation activity of Th1 and/or Th2 lymphocytes. This gene is mapped to human chromosome 4q31 by fluorescence in situ hybridization. IL-15 is a novel cytokine whose effects on T-cell activation and proliferation are similar to those of interleukin-2 (IL-2), presumably because IL-15 utilizes the beta and gamma chains of the IL-2 receptor. IL-15 can play a role in the initiation and outcome of acute and chronic rejection. Anti-IL-15 therapy in combination with classic immunosuppression therapy might be beneficial in the prevention of acute, and especially chronic, allograft rejection.

Synonyms

Interleukin-15; IL-15; IL15

Gene Name

IL15

Gene ID

3600

UniProt

P40933

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human IL-15 recombinant protein (Position: N49-S162) . Human IL-15 shares 70% amino acid (aa) sequence identity with both mouse and rat IL-15.

Clonality

Polyclonal

Tissue Specificity

Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus.

Applications

ELISA, WB

Field of Research

Antiviral Signaling, Cancer, Cytokines, Immune System Diseases, Immunology, Innate Immunity, Interleukins, Metabolism, NK Cells, Obesity, Tumor Immunology

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

References & Citations

1. Anderson, D. M.; Johnson, L.; Glaccum, M. B.; Copeland, N. G.; Gilbert, D. J.; Jenkins, N. A.; Valentine, V.; Kirstein, M. N.; Shapiro, D. N.; Morris, S. W.; Grabstein, K.; Cosman, D. Chromosomal assignment and genomic structure of IL15. Genomics 25: 701-706, 1995. 2. Conti F, Frappier J, Dharancy S, Chereau C, Houssin D, Weill B, Calmus Y. Interleukin-15 production during liver allograft rejection in humans. Transplantation. 2003 Jul 15;76 (1) :210-6.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

18086 MW

Observed Molecular Weight

15 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Interleukin-15

Subcellular Location

Isoform IL15-S48AA: Secreted.

Sequence Similarities

Belongs to the IL-15/IL-21 family.

Protein Name

Interleukin-15

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.