Anti-KCND1 Antibody Picoband®

About this product

Boster Bio Anti-KCND1 Antibody Picoband® catalog # PB9256. Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9256

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as Kv4.1, is a human gene. It is mapped to Xp11.23. KCND1 encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. The diverse functions of Voltage-gated potassium (Kv) channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. In addition to that, KCND1 is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle.

Synonyms

Potassium voltage-gated channel subfamily D member 1; Voltage-gated potassium channel subunit Kv4.1; KCND1

Gene Name

KCND1

Gene ID

3750

UniProt

Q9NSA2

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human KCND1 recombinant protein (Position: T442-L647) . Human KCND1 shares 90% amino acid (aa) sequence identity with mouse KCND1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain. .

Applications

WB

Field of Research

Neuroscience, Neurotransmission, Potassium Channels, Receptors / Channels

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I (To) current in heart and I (Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

References & Citations

1. Entrez Gene: KCND1 potassium voltage-gated channel, Shal-related subfamily, member 1 2. Isbrandt, D., Leicher, T., Waldschutz, R., Zhu, X., Luhmann, U., Michel, U., Sauter, K., Pongs, O. Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I (to) and I (sa) . Genomics 64: 144-154, 2000.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

71330 MW

Observed Molecular Weight

71 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Potassium voltage-gated channel subfamily D member 1

Subcellular Location

Membrane; Multi-pass membrane protein. Cell projection, dendrite .

Sequence Similarities

Belongs to the integrin alpha chain family.

Protein Name

Potassium voltage-gated channel subfamily D member 1

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.