Anti-Kallikrein 4/KLK4 Antibody Picoband®

About this product

Boster Bio Anti-Kallikrein 4/KLK4 Antibody Picoband® catalog # PB9260. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9260

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Kallikrein-related peptidase 4, also known as PSTS or EMSP1, is a protein which in humans is encoded by the KLK4 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In particular, they may serve as biomarkers for both prostate cancer and breast cancer. It has been found that KLK4 is a proliferative factor with effects on gene expression and it may have a role in prostate cancer development and progression.

Synonyms

Kallikrein-4;3.4.21.-; Enamel matrix serine proteinase 1; Kallikrein-like protein 1; KLK-L1; Prostase; Serine protease 17; KLK4; EMSP1, PRSS17, PSTS

Gene Name

KLK4

Gene ID

9622

UniProt

Q9Y5K2

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human Kallikrein 4 recombinant protein (Position: I31-S254) .

Clonality

Polyclonal

Tissue Specificity

Expressed in prostate.

Applications

WB

Field of Research

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Involved in enamel formation. .

References & Citations

1. Klokk, T. I., Kilander, A., Xi, Z., Waehre, H., Risberg, B., Danielson, H. E., Saatcioglu, F. Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer. Cancer Res. 67: 5221-5230, 2007. 2. Nelson PS, Gan L, Ferguson C, Moss P, Gelinas R, Hood L, Wang K (March 1999) . 3. Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD (June 2000) .

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

27032 MW

Observed Molecular Weight

27 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Kallikrein-4

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Protein Name

Kallikrein-4

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.