Anti-TRPC5 Antibody Picoband®

About this product

Boster Bio Anti-TRPC5 Antibody Picoband® catalog # PB9271. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9271

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Short transient receptor potential channel 5 (TrpC5), also known as TRP-5, is a protein that in humans is encoded by the TRPC5 gene. TRPC5 is subtype of the TRPC family of mammalian transient receptor potential ion channels. It is mapped to Xq23. The predicted 973-amino acid TRPC5 protein has a calculated molecular mass of 111.5 kD. It contains the characteristic 8 predicted transmembrane domains (TM1 through TM8), including a pore region (TM7) between TM6 and TM8. TRPC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel, and it is a candidate for the regulation of calcium waves. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4.

Synonyms

Short transient receptor potential channel 5; TrpC5; Transient receptor protein 5; TRP-5; hTRP-5; hTRP5; TRPC5; TRP5

Gene Name

TRPC5

Gene ID

7224

UniProt

Q9UL62

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human TRPC5 recombinant protein (Position: K684-L973) . Human TRPC5 shares 90% amino acid (aa) sequence identity with mouse TRPC5.

Clonality

Polyclonal

Tissue Specificity

Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole. .

Applications

WB

Field of Research

Calcium Channels, Calcium Signaling, Metabolism, Neuroscience, Neurotransmission, Plasma Membrane, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity) . May also be activated by intracellular calcium store depletion. .

References & Citations

1. Entrez Gene: transient receptor potential cation channel 2. Greka, A., Navarro, B., Oancea, E., Duggan, A., Clapham, D. E. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nature Neurosci. 6: 837-845, 2003. 3. Sossey-Alaoui, K., Lyon, J. A., Jones, L., Abidi, F. E., Hartung, A. J., Hane, B., Schwartz, C. E., Stevenson, R. E., Srivastava, A. K. Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca (2+) entry channel. Genomics 60: 330-340, 1999.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

111412 MW

Observed Molecular Weight

111 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Short transient receptor potential channel 5

Subcellular Location

Cell membrane ; Multi-pass membrane protein .

Sequence Similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.

Protein Name

Short transient receptor potential channel 5

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.