Anti-Peroxiredoxin 6/PRDX6 Antibody Picoband®

About this product

Boster Bio Anti-Peroxiredoxin 6/PRDX6 Antibody Picoband® catalog # PB9350. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9350

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

PRDX6 is also known as PRX, p29 or AOP2. The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H (2) O (2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

Synonyms

Peroxiredoxin-6;1.11.1.15;1-Cys peroxiredoxin;1-Cys PRX;24 kDa protein; Acidic calcium-independent phospholipase A2; aiPLA2;3.1.1.-; Antioxidant protein 2; Liver 2D page spot 40; Non-selenium glutathione peroxidase; NSGPx;1.11.1.9; Red blood cells page spot 12; PRDX6; AOP2, KIAA0106

Gene Name

PRDX6

Gene ID

9588

UniProt

P30041

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Peroxiredoxin 6 recombinant protein (Position: E15-P224) . Human Peroxiredoxin 6 shares 90% and 91% amino acid (aa) sequence identity with mouse and rat Peroxiredoxin 6, respectively.

Clonality

Polyclonal

Tissue Specificity

Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.

Applications

IHC, ICC, WB

Field of Research

Atherosclerosis, Cancer, Cancer Metabolism, Cardiovascular, Cell Biology, Heart Disease, Lipid Metabolism, Metabolism, Mitochondrial Markers, Mitochondrial Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism, Signal Transduction, Vascular Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Involved in redox regulation of the cell. Can reduce H (2) O (2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

References & Citations

1. Ambruso DR, et al. Peroxiredoxin 6 translocates to the plasma membrane during neutrophil activation and is required for optimal NADPH oxidase activity. Biochim Biophys Acta, 2012 Feb. 2. Chhunchha B, et al. Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription. FEBS J, 2014 Aug. 3. Guo HW, et al. Expression of peroxiredoxin 6 in gastric cancer and its clinical significance. Zhonghua Yi Xue Za Zhi, 2012 Sep 11.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

25035 MW

Observed Molecular Weight

25 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Peroxiredoxin-6

Subcellular Location

Cytoplasm . Lysosome . Cytoplasmic vesicle . Also found in lung secretory organelles. .

Sequence Similarities

Belongs to the AhpC/TSA family. Rehydrin subfamily.

Protein Name

Peroxiredoxin-6

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.