Anti-RBP4 Antibody Picoband®

About this product

Boster Bio Anti-RBP4 Antibody Picoband® catalog # PB9360. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9360

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

RBP4 is also known as RDCCAS. This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.

Synonyms

Retinol-binding protein 4; Plasma retinol-binding protein; PRBP; RBP; Plasma retinol-binding protein (1-182) ; Plasma retinol-binding protein (1-181) ; Plasma retinol-binding protein (1-179) ; Plasma retinol-binding protein (1-176) ; RBP4; PRO2222

Gene Name

RBP4

Gene ID

5950

UniProt

P02753

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RBP4 recombinant protein (Position: E19-201L) . Human RBP4 shares 86% amino acid (aa) sequence identity with both mouse and rat RBP4.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone- independent mammary carcinoma cell lines. .

Applications

ELISA, IF, IHC, WB

Field of Research

Atherosclerosis, Cancer, Cardiovascular, Cofactors, Vitamins/Minerals, Diabetes, Diabetes-associated, Heart Disease, Metabolism, Pathways and Processes, Serum Proteins, Signal Transduction, Vitamins/Minerals

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

References & Citations

1. Cubedo J, et al. Retinol-binding protein 4 levels and susceptibility to ischaemic events in men. Eur J Clin Invest, 2014. 2. Li F, et al. Retinol-binding protein 4 as a novel risk factor for cardiovascular disease in patients with coronary artery disease and hyperinsulinemia. Am J Med Sci, 2014 Dec. 3. Saucedo R, et al. RBP4 gene variants are associated with insulin resistance in women with previous gestational diabetes. Dis Markers, 2014.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

23 kDa

Observed Molecular Weight

23 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Retinol-binding protein 4

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the calycin superfamily. Lipocalin family.

Protein Name

Retinol-binding protein 4

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.