Anti-SFRP2 Antibody Picoband®

About this product

Boster Bio Anti-SFRP2 Antibody Picoband® catalog # PB9362. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9362

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

SFRP2 is also known as FRP-2, SARP1 or SDF-5. It is Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon. This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.?

Synonyms

Secreted frizzled-related protein 2; FRP-2; sFRP-2; Secreted apoptosis-related protein 1; SARP-1; SFRP2; FRP2, SARP1; FKSG12, UNQ361/PRO697

Gene Name

SFRP2

Gene ID

6423

UniProt

Q96HF1

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SFRP2 recombinant protein (Position: L104-C295) . Human SFRP2?shares?99%?amino?acid? (aa) ?sequence?identity?with mouse SFRP2.

Clonality

Polyclonal

Tissue Specificity

Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon. .

Applications

ELISA, WB

Field of Research

Angiogenesis, Cancer, Cardiogenesis, Cardiovascular, Invasion/Microenvironment, Mesenchymal Stem Cells, Secreted, Signaling Pathways, Stem Cells, Transcription Factors/Regulators

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

References & Citations

1. Hao XW, et al. Epigenetic inactivation of secreted frizzled-related protein 2 in esophageal squamous cell carcinoma. World J Gastroenterol, 2012 Feb 14. 2. O'Hurley G, et al. The role of secreted frizzled-related protein 2 expression in prostate cancer. Histopathology, 2011 Dec. 3. Sui C, et al. Variation risks of SFRP2 hypermethylation between precancerous disease and colorectal cancer. Tumour Biol, 2014 Oct.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

33490 MW

Observed Molecular Weight

33 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Secreted frizzled-related protein 2

Subcellular Location

Secreted .

Sequence Similarities

Belongs to the secreted frizzled-related protein (sFRP) family.

Protein Name

Secreted frizzled-related protein 2

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.