Anti-beta 2 Adrenergic Receptor/ADRB2 Antibody Picoband®

About this product

Boster Bio Anti-beta 2 Adrenergic Receptor/ADRB2 Antibody Picoband® catalog # PB9365. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9365

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

ADRB2, also known as beta-2 adrenergic receptor, is a beta-adrenergic receptor within a cell membrane which reacts with adrenaline (epinephrine) as a hormone or neurotransmitter affecting muscles or organs. It is mapped to 5q32. This receptor is ly associated with one of its ultimate effectors, the class C L-type calcium channel Ca (V) 1.2. The genetic variation in the ADRB2 gene may be of major importance for obesity, energy expenditure, and lipolytic ADRB2 function in adipose tissue, at least in women. What’ s more, it has been found that activation of ADRB2 receptors can stimulate gamma-secretase activity and beta-amyloid production, and the ADRB2 receptors activator may contribute to beta-amyloid accumulation in AD.

Synonyms

Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor; ADRB2; ADRB2R, B2AR

Gene Name

ADRB2

Gene ID

154

UniProt

P07550

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human ADRB2, different from the related mouse and rat sequences by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Applications

WB

Field of Research

Adaptive Immunity, Angiogenesis, Atherosclerosis, Cardiovascular, Cell Adhesion Molecules, Cell Type Markers, Hematopoietic Progenitors, Immunology, Myeloid, Platelets, Stem Cells, Vascular Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

References & Citations

1. Entrez Gene: ADRB2 adrenergic, beta-2-, receptor, surface 2. Large, V., Hellstrom, L., Reynisdottir, S., Lonnqvist, F., Eriksson, P., Lannfelt, L., Arner, P.Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function. J. Clin. Invest. 100: 3005-3013, 1997. 3. Ni, Y., Zhao, X., Bao, G., Zou, L., Teng, L., Wang, Z., Song, M., Xiong, J., Bai, Y., Pai, G.Activation of beta-2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation. Nature Med. 12: 1390-1396, 2006.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

46459 MW

Observed Molecular Weight

47 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Beta-2 adrenergic receptor

Subcellular Location

Cell membrane ; Multi-pass membrane protein . Colocalizes with VHL at the cell membrane.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.

Protein Name

Beta-2 adrenergic receptor

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.