Anti-HLA A/HLA-A Antibody Picoband®

About this product

Boster Bio Anti-HLA A/HLA-A Antibody Picoband® catalog # PB9376. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9376

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

HLA-A, namely HLA A, is a group of human leukocyte antigens (HLA) that are coded for by the HLA-A locus, which is located at human chromosome 6p21.3. HLA is simply the major histocompatibility complex (MHC) specific to humans. HLA-A is one of three major types of human MHC class I cell surface receptors. The others are HLA-B and HLA-C. And it is critical to the cytotoxic t-cell controlled immune response to viruses and other intracellular pathogens. Because each HLA-A gene has a high affinity for slightly different peptides, certain HLA-As are associated with increased risk, more rapid progression, and/or increased severity of many diseases. For similar reasons, HLA-A matching is essential to successful tissue transplants.

Synonyms

HLA class I histocompatibility antigen, A-2 alpha chain; MHC class I antigen A*2; HLA-A; HLAA

Gene Name

HLA-A

Gene ID

3105

UniProt

P01892

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human HLA A.

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.

Applications

IF, IHC, ICC, WB

Field of Research

Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Involved in the presentation of foreign antigens to the immune system.

References & Citations

1. HLA Nomenclature @ hla.alleles.org. Anthony Nolan Research Institute. 10 Nov 2013. Retrieved 8 Dec 2013. 2. Statistics. European Bioinformatics Institute (EBI) / European Molecular Biology Laboratory (EMBL) . Retrieved 13 Dec 2013.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

40922 MW

Observed Molecular Weight

41 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

HLA class I histocompatibility antigen, A-2 alpha chain

Subcellular Location

Membrane; Single-pass type I membrane protein.

Sequence Similarities

Belongs to the MHC class I family.

Protein Name

HLA class I histocompatibility antigen, A-2 alpha chain

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.