Anti-SOX1 Antibody Picoband®

About this product

Boster Bio Anti-SOX1 Antibody Picoband® catalog # PB9403. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9403

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

SOX1 (for Sex determining region Y-box 1), located in 13q34, is a transcription factor in the Sox protein family. It means that this intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. SOX1 expression is restricted to neuroectodermin the tetrapod embryo. It is expressed particularly in the ventral striatum.

Synonyms

Transcription factor SOX-1; SOX1

Gene Name

SOX1

Gene ID

6656

UniProt

O00570

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of Human SOX1, identical to the related mouse sequence.

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in the developing central nervous system.

Applications

WB

Field of Research

Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Intracellular, Neural Stem Cells, Neurogenesis, Neurology Process, Neuroscience, Stem Cells, Transcription

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) . .

References & Citations

1. Guth SI, Wegner M (October 2008) . Having it both ways: Sox protein function between conservation and innovation. Cell. Mol. Life Sci. 65 (19) : 3000–18. 2. Jump up^ Nitta KR, Takahashi S, Haramoto Y, Fukuda M, Onuma Y, Asashima M (December 2006) . Expression of Sox1 during Xenopus early embryogenesis. Biochem. Biophys. Res. Commun. 351 (1) : 287–93.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

39023 MW

Observed Molecular Weight

39 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Transcription factor SOX-1

Subcellular Location

Nucleus .

Sequence Similarities

Belongs to the Cu-Zn superoxide dismutase family.

Protein Name

Transcription factor SOX-1

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.