Anti-CTBP2 Antibody Picoband®

About this product

Boster Bio Anti-CTBP2 Antibody Picoband® catalog # PB9426. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9426

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The E1a region of group C adenoviruses encodes 2 nearly identical proteins that are largely responsible for the oncogenic properties of adenoviruses. The CTBP1 protein binds to the C-terminal half of these E1A proteins. It's predicted that CTBP2 is a 445-amino acid protein and it is 72% identical to CTBP1. The CTBP2 gene is mapped to chromosome 10q26.13. CTBP2 is a mammalian corepressor that targets diverse transcriptional regulators. It bounds the short medial portion of delta-EF1 containing the PLDLSL motif and it enhances transrepression activity of delta-EF1.

Synonyms

C-terminal-binding protein 2; CtBP2; CTBP2

Gene Name

CTBP2

Gene ID

1488

UniProt

P56545

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human CTBP2 recombinant protein (Position: H321-Q445) . Human CTBP2 shares 99.2% and 98.4% amino acid (aa) sequence identity with mouse and rat CTBP2, respectively.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.

Applications

Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Cell Type Marker, Co-Factors, Epigenetics and Nuclear Signaling, Microbiology, Neuron Marker, Neuroscience, Synapse Marker, Transcription

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity) . .

References & Citations

1. Furusawa, T., Moribe, H., Kondoh, H., Higashi, Y.Identification of CtBP1 and CTBP2 as corepressors of zinc finger-homeodomain factor delta-EF1.Molec. Cell. Biol. 19: 8581-8590, 1999. 2. Thomas, G., Jacobs, K. B., Yeager, M., Kraft, P., Wacholder, S., Orr, N., Yu, K., Chatterjee, N., Welch, R., Hutchinson, A., Crenshaw, A., Cancel-Tassin, G., and 27 others.Multiple loci identified in a genome-wide association study of prostate cancer.Nature Genet. 40: 310-315, 2008. 3. Turner, J., Crossley, M.Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators.EMBO J. 17: 5129-5140, 1998.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

48945 MW

Observed Molecular Weight

50 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

C-terminal-binding protein 2

Subcellular Location

Nucleus . Cell junction, synapse .

Sequence Similarities

Belongs to the cyclin family. Cyclin AB subfamily.

Protein Name

C-terminal-binding protein 2

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.