Anti-ITPR3 Antibody Picoband®

About this product

Boster Bio Anti-ITPR3 Antibody Picoband® catalog # PB9428. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9428

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

ITPR3 encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.

Synonyms

Inositol 1,4,5-trisphosphate receptor type 3; IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor; ITPR3

Gene Name

ITPR3

Gene ID

3710

UniProt

Q14573

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human ITPR3, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed in intestinal crypt and villus epithelial cells.

Applications

IHC, WB

Field of Research

Calcium Channels, Calcium Signaling, Neuroscience, Neurotransmission, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

References & Citations

1. Entrez Gene: inositol 1. 2. Chaudhari N, Roper SD (August 2010) .The cell biology of taste. J. Cell Biol.190 (3) : 285–96. 3. Yamamoto-Hino M, Sugiyama T, Hikichi K et al. (1994) . Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.Recept. Channels 2 (1) : 9–22.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

304106 MW

Observed Molecular Weight

270-300 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Inositol 1,4,5-trisphosphate receptor type 3

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the InsP3 receptor family.

Protein Name

Inositol 1,4,5-trisphosphate receptor type 3

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.