Anti-Glucose Transporter GLUT2/SLC2A2 Antibody Picoband®

About this product

Boster Bio Anti-Glucose Transporter GLUT2/SLC2A2 Antibody Picoband® catalog # PB9436. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9436

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

SLC2A2, also known as Glucose transporter 2 (GLUT2), is a transmembrane carrier protein that enables protein facilitatedglucose movement across cell membranes. This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated biional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM) . Alternative splicing results in multiple transcript variants of this gene.

Synonyms

Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2; SLC2A2; GLUT2

Gene Name

SLC2A2

Gene ID

6514

UniProt

P11168

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SLC2A2, different from the related mouse sequence by five amino acids, and from the related rat sequence by seven amino acids.

Clonality

Polyclonal

Tissue Specificity

Liver, insulin-producing beta cell, small intestine and kidney.

Applications

IHC, WB

Field of Research

Cancer, Cancer Metabolism, Carbohydrate Metabolism, Developmental Biology, Energy Metabolism, Energy Transfer Pathways, Lineage Markers, Lineage Specification, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Carbohydrates, Metabolism of Lipids and Lipoproteins, Pathways and Processes, Signal Transduction, Stem Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Facilitative glucose transporter. This isoform likely mediates the biional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na (+) /glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

References & Citations

1. Froguel P, Zouali H, Sun F, Velho G, Fukumoto H, Passa P, Cohen D (July 1991) .CA repeat polymorphism in the glucose transporter GLUT 2 gene. Nucleic Acids Res. 19 (13) : 3754. 2. Santer R, Groth S, Kinner M, Dombrowski A, Berry GT, Brodehl J, Leonard JV, Moses S, Norgren S, Skovby F, Schneppenheim R, Steinmann B, Schaub J (January 2002) . The mutation spectrum of the facilitative glucose transporter gene SLC2A2 (GLUT2) in patients with Fanconi-Bickel syndrome.Hum. Genet. 110 (1) : 21–9. 3. Uldry M, Ibberson M, Hosokawa M, Thorens B (July 2002) . GLUT2 is a high affinity glucosamine transporter. FEBS Lett. 524 (1-3) : 199–203.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

57490 MW

Observed Molecular Weight

50 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Solute carrier family 2, facilitated glucose transporter member 2

Subcellular Location

Membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Protein Name

Solute carrier family 2, facilitated glucose transporter member 2

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.