Anti-Tyrosine Hydroxylase/TH Antibody Picoband®

About this product

Boster Bio Anti-Tyrosine Hydroxylase/TH Antibody Picoband® catalog # PB9449. Tested in IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9449

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

TH is equal to tyrosine hydroxylase. The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral sympathetic neurons and the adrenal medulla. Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases (AAAHs) .

Synonyms

Tyrosine 3-monooxygenase;1.14.16.2; Tyrosine 3-hydroxylase; TH; TH; TYH

Gene Name

TH

Gene ID

7054

UniProt

P07101

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Tyrosine Hydroxylase, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in the brain and adrenal glands.

Applications

IF, IHC, WB

Field of Research

Cancer, Cancer Metabolism, Cell Type Marker, Endocrine Metabolism, Hormone Biosynthesis, Hypoxia, Metabolic Signaling Pathway, Metabolism, Metabolism Processes, Neuron Marker, Neuroscience, Neurotransmitter, Pathways and Processes, Response To Hypoxia

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Plays an important role in the physiology of adrenergic neurons.

References & Citations

1. Haavik J, Toska K (June 1998) . Tyrosine hydroxylase and Parkinson's disease. Mol. Neurobiol. 16 (3) : 285–309. 2. Kaufman S (1995) . Tyrosine hydroxylase. Adv. Enzymol. Relat. Areas Mol. Biol. Advances in Enzymology - and Related Areas of Molecular Biology 70: 103–220. Nagatsu T (1995) . Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology. Essays Biochem.30: 15–35.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

58600 MW

Observed Molecular Weight

59 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Tyrosine 3-monooxygenase

Sequence Similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Protein Name

Tyrosine 3-monooxygenase

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.