Anti-ARSA Antibody Picoband®

About this product

Boster Bio Anti-ARSA Antibody Picoband® catalog # PB9477. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9477

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Arylsulfatase A (ARSA) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate intocerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene. ARSA is mapped to 22q13.33. The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.

Synonyms

Arylsulfatase A; ASA;3.1.6.8; Cerebroside-sulfatase; Arylsulfatase A component B; Arylsulfatase A component C; ARSA

Gene Name

ARSA

Gene ID

410

UniProt

P15289

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human ARSA, different from the related mouse sequence by six amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD) . .

Applications

Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Cancer, Cell Biology, Cell Death, Metabolism, Metabolism Processes, Neurodegenerative Disease, Neurology Process, Neuroscience, Organelles, Pathways and Processes, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Hydrolyzes cerebroside sulfate.

References & Citations

1. Fujii T; Kobayashi T; Honke K et al. (1992) . Proteolytic processing of human lysosomal arylsulfatase A. Biochim. Biophys. Acta 1122 (1) : 93–8. 2. Kondo R; Wakamatsu N; Yoshino H et al. (1991) .Identification of a mutation in the arylsulfatase A gene of a patient with adult-type metachromatic leukodystrophy. Am. J. Hum. Genet. 48 (5) : 971–8. 3. Matzner U, Herbst E, Hedayati KK, Lüllmann-Rauch R, Wessig C, Schröder S, Eistrup C, Möller C, Fogh J, Gieselmann V (May 2005) . Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy. Hum. Mol. Genet. 14 (9) : 1139–52.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

54 kDa

Observed Molecular Weight

54 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Arylsulfatase A

Subcellular Location

Lysosome.

Sequence Similarities

Belongs to the sulfatase family.

Protein Name

Arylsulfatase A

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.