Anti-CTGF Antibody Picoband®

About this product

Boster Bio Anti-CTGF Antibody Picoband® catalog # PB9541. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9541

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein) . CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair, and is critically involved in fibrotic disease and several forms of cancers. The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. And the encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.

Synonyms

Connective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8; CTGF; CCN2, HCS24, IGFBP8

Gene Name

CTGF

Gene ID

1490

UniProt

P29279

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human CTGF recombinant protein (Position: R58-A349) . Human CTGF shares 95.5% and 95.9% amino acid (aa) sequence identity with mouse and rat CTGF, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. .

Applications

IHC, WB

Field of Research

Angiogenesis, Cardiovascular, Growth Factors, Immunology, Secreted Molecules

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. .

References & Citations

1. Chen CC, Lau LF (April 2009) . Functions and mechanisms of action of CCN matricellular proteins. Int. J. Biochem. Cell Biol. 41 (4) : 771–83. 2. Hall-Glenn F, Lyons KM (October 2011) . Roles for CCN2 in normal physiological processes. Cell. Mol. Life Sci. 68 (19) : 3209–17. 3. Jun JI, Lau LF (December 2011) . Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov 10 (12) : 945–63.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

38091 MW

Observed Molecular Weight

38 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Connective tissue growth factor

Subcellular Location

Secreted, extracellular space, extracellular matrix . Secreted .

Sequence Similarities

Belongs to the CCN family.

Protein Name

Connective tissue growth factor

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.