Anti-G-CSF/CSF3 Antibody Picoband®

About this product

Boster Bio Anti-G-CSF/CSF3 Antibody Picoband® catalog # PB9577. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9577

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Granulocyte-colony stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. The pharmaceutical analogs of naturally occurring G-CSF are called filgrastim and lenograstim. G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils.

Synonyms

Granulocyte colony-stimulating factor; G-CSF; Csf3; Csfg

Gene Name

Csf3

Gene ID

12985

UniProt

P09920

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived mouse G-CSF recombinant protein (Position: R47-A208) . Mouse G-CSF shares 77.2% amino acid (aa) sequence identity with human G-CSF.

Clonality

Polyclonal

Tissue Specificity

Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle. .

Applications

ELISA, WB

Field of Research

Angiogenesis, Cancer, Cytokines, Immunology, Innate Immunity, Invasion/Microenvironment

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

References & Citations

1. Metcalf D (July 1985) . The granulocyte-macrophage colony-stimulating factors. Science 229 (4708) : 16–22. 2. Nagata S, Tsuchiya M, Asano S, Kaziro Y, Yamazaki T, Yamamoto O, Hirata Y, Kubota N, Oheda M, Nomura H (1986) . Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor. Nature 319 (6052) : 415–8. 3. Souza LM, Boone TC, Gabrilove J, Lai PH, Zsebo KM, Murdock DC, Chazin VR, Bruszewski J, Lu H, Chen KK, Barendt J, Platzer, E, Moore, MAS, Mertelsmann R, Welte K (April 1986) . Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells. Science 232 (4746) : 61–5.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

22421 MW

Observed Molecular Weight

22 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Granulocyte colony-stimulating factor

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the DNA photolyase class-1 family.

Protein Name

Granulocyte colony-stimulating factor

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.