Anti-SOX4 Antibody Picoband®

About this product

Boster Bio Anti-SOX4 Antibody Picoband® catalog # PB9618. Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9618

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene. This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin) . This protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.

Synonyms

Transcription factor SOX-4; SOX4

Gene Name

SOX4

Gene ID

6659

UniProt

Q06945

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human SOX4, identical to the related mouse sequence.

Clonality

Polyclonal

Tissue Specificity

Testis, brain, and heart.

Applications

WB

Field of Research

Cell Type Marker, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Intracellular, Neural Signal Transduction, Neural Stem Cells, Neurology Process, Neuroscience, Stem Cells, Transcription

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

References & Citations

1. Entrez Gene: SOX4 SRY (sex determining region Y) -box 4. 2. Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (October 1998) . Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3. Cytogenet Cell Genet81 (3–4) : 294–5. 3. Farr CJ, Easty DJ, Ragoussis J, Collignon J, Lovell-Badge R, Goodfellow PN (January 1994) . Characterization and mapping of the human SOX4 gene. Mamm Genome 4 (10) : 577–84.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

47263 MW

Observed Molecular Weight

47 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Transcription factor SOX-4

Subcellular Location

Nucleus .

Sequence Similarities

Contains 1 HMG box DNA-binding domain.

Protein Name

Transcription factor SOX-4

Isotype

Rabbit IgG

Contents

243