Anti-PTOV1 Antibody Picoband®

About this product

Boster Bio Anti-PTOV1 Antibody catalog # RP1087. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

RP1087

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Prostate tumor overexpressed gene 1 protein is a protein that in humans is encoded by the PTOV1 gene. It is mapped to 19q13.33. This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants.

Synonyms

Prostate tumor-overexpressed gene 1 protein; PTOV-1; Activator interaction domain-containing protein 2; PTOV1; ACID2; PP642, UNQ6127/PRO20092

Gene Name

PTOV1

Gene ID

53635

UniProt

Q86YD1

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human PTOV1, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Expressed in brain, heart, kidney, liver, placenta, skeletal muscle and small intestine. .

Applications

WB

Field of Research

Cancer, Cell Cycle, Cell Division, Epigenetics and Nuclear Signaling, Transcription, Transcription Factors, Tumor Antigens, Tumor Biomarkers

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. .

References & Citations

1. Entrez Gene: PTOV1 prostate tumor overexpressed gene 1. 2. Santamaria A, Castellanos E, Gomez V, Benedit P, Renau-Piqueras J, Morote J, Reventos J, Thomson TM, Paciucci R (Feb 2005) . PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. Mol Cell Biol 25 (5) : 1900–11. 3. Santamaria A, Fernandez PL, Farre X, Benedit P, Reventos J, Morote J, Paciucci R, Thomson TM (Feb 2003) .PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. Am J Pathol 162 (3) : 897–905.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

46869 MW

Observed Molecular Weight

47 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Prostate tumor-overexpressed gene 1 protein

Subcellular Location

Cell membrane. Cytoplasm, perinuclear region. Nucleus. Translocates from the cytoplasm to the nucleus at the onset of S-phase. Also localizes to lipid rafts.

Sequence Similarities

Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.

Protein Name

Prostate tumor-overexpressed gene 1 protein

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.