Anti-ING1 Antibody Picoband®

About this product

Boster Bio Anti-ING1 Antibody Picoband® catalog # PB9644. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9644

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene. It is mapped to 13q34. This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Synonyms

Inhibitor of growth protein 1; ING1

Gene Name

ING1

Gene ID

3621

UniProt

Q9UK53

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human ING1, different from the related mouse sequence by seven amino acids.

Clonality

Polyclonal

Tissue Specificity

Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines. .

Applications

WB

Field of Research

Acetylation, Apoptosis, Cancer, Cancer Susceptibility, Cell Biology, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Intracellular, Oncoproteins/Suppressors, p53 Pathway, Transcription, Tumor Suppressors

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. .

References & Citations

1. Entrez Gene: ING1 inhibitor of growth family, member 1. 2. Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Jan 1997) . Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. Nat Genet 14 (4) : 415–20. 3. Garkavtsev I, Demetrick D, Riabowol K (Jul 1997) . Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1) . Cytogenet Cell Genet 76 (3-4) : 176–8.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

46738 MW

Observed Molecular Weight

47 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Inhibitor of growth protein 1

Subcellular Location

Nucleus .

Sequence Similarities

Contains 1 HMG box DNA-binding domain.

Protein Name

Inhibitor of growth protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.