Anti-IP10/CXCL10 Antibody Picoband®

About this product

Boster Bio Anti-IP10/CXCL10 Antibody Picoband® catalog # PB9696. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9696

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

C-X-C motif chemokine 10 (CXCL10), also known as Interferon gamma-induced protein 10 kDa (IP-10) or small-inducible cytokine B10, is a protein that in humans is encoded by the CXCL10 gene. It is a small cytokine belonging to the CXC chemokine family. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. Luster et al. (1987) reported the isolation of an interferon-inducible gene that encodes a 98-amino acid protein called IP10. The chemokine IFN-gamma-inducible protein 10 (IP-10; CXCL10), a CXC chemokine, and its receptor, CXCR3, were found to be overexpressed in lymph node cells of EAMG rats. IP10 inhibits bone marrow colony formation, has antitumor activity in vivo, is a chemoattractant for human monocytes and T cells, and promotes T cell adhesion to endothelial cells.

Synonyms

C-X-C motif chemokine 10;10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10; Cxcl10; Crg2, Ifi10, Inp10, Scyb10

Gene Name

Cxcl10

Gene ID

15945

UniProt

P17515

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived mouse IP10 recombinant protein (Position: I22-P98) . Mouse IP10 shares 70.1% and 77.9% amino acid (aa) sequence identity with human and rat IP10, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in the spleen, thymus, lymph nodes and liver. .

Applications

ELISA, IHC, WB

Field of Research

Angiogenesis, Cancer, Chemokines, Immunology, Innate Immunity, Invasion/Microenvironment

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.

References & Citations

1. Feferman, T., Maiti, P. K., Berrih-Aknin, S., Bismuth, J., Bidault, J., Fuchs, S., Souroujon, M. C.Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis.J. Immun.174: 5324-5331, 2005. 2. Luster AD, Unkeless JC, Ravetch JV (1985) . Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315 (6021) : 672–6. 3. Luster AD, Jhanwar SC, Chaganti RS, Kersey JH, Ravetch JV (May 1987) . Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells. Proc. Natl. Acad. Sci. U.S.A. 84 (9) : 2868–71.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

10789 MW

Observed Molecular Weight

19 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

C-X-C motif chemokine 10

Subcellular Location

Secreted.

Protein Name

C-X-C motif chemokine 10

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.