Anti-ELAVL4 Antibody Picoband®

About this product

Boster Bio Anti-ELAVL4 Antibody Picoband® catalog # PB9698. Tested in IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9698

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

HuD?otherwise known as?ELAV-like protein 4 or PNEM?is a?protein?that in humans is encoded by the?ELAVL4?gene. This human gene is located at 1p34 by in situ hybridization. The HuD/ELAVL4 protein is an?RNA-binding protein. ELAVL4?has specificity for 3-prime uridylate-rich untranslated regions of growth factor mRNAs. And HuD is expressed only in neurons and it binds to?AU-rich element-containing mRNAs. As a result of this interaction the, half-life of the transcript is increased. Also, HuD is important in neurons during brain development and plasticity.

Synonyms

ELAV-like protein 4; Hu-antigen D; HuD; Paraneoplastic encephalomyelitis antigen HuD; ELAVL4; HUD, PNEM

Gene Name

ELAVL4

Gene ID

1996

UniProt

P26378

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human ELAVL4, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Brain.

Applications

IF, IHC, WB

Field of Research

Cell Type Marker, DNA/RNA, Epigenetics and Nuclear Signaling, Intracellular, Neural Stem Cells, Neuron Marker, Neuroscience, RNA Processing, Stem Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity) . Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA. .

References & Citations

1. Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila) -like 4 (Hu antigen D) . 2. Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M (Dec 1993) . Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34. Cytogenet Cell Genet 65 (3) : 177–8. 3. Nora Perrone-Bizzozero and Federico Bolognani (2002) . Role of HuD and other RNA-binding proteins in neural development and plasticity. J Neurosci Res 68 (2) : 121–126.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

41770 MW

Observed Molecular Weight

42 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

ELAV-like protein 4

Subcellular Location

Secreted.

Protein Name

ELAV-like protein 4

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.