Anti-LOX Antibody Picoband®

About this product

Boster Bio Anti-LOX Antibody Picoband® catalog # PB9718. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9718

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Lysyl oxidase  (LOX), also known as  protein-lysine 6-oxidase, is a  protein  that, in humans, is encoded by the LOX  gene. The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I) . Two transcript variants encoding different isoforms have been found for this gene.&nbsp

Synonyms

Protein-lysine 6-oxidase;1.4.3.13; Lysyl oxidase; LOX

Gene Name

LOX

Gene ID

4015

UniProt

P28300

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human LOX, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Heart, placenta, skeletal muscle, kidney, lung and pancreas. .

Applications

ELISA, WB

Field of Research

Atherosclerosis, Cancer, Cardiovascular, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction, Vascular Inflammation, Vasculature

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a role in tumor suppression.

References & Citations

1. Hamalainen, E.-R., Jones, T. A., Sheer, D., Taskinen, K., Pihlajaniemi, T., Kivirikko, K. I. Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2. Genomics 11: 508-516, 1991. 2. Kuivaniemi, H., Savolainen, E.-R., Kivirikko, K. I. Human placental lysyl oxidase: purification, partial characterization, and preparation of two specific antisera to the enzyme. J. Biol. Chem. 259: 6996-7002, 1984. 3. Li, W., Nellaiappan, K., Strassmaier, T., Graham, L., Thomas, K. M., Kagan, H. M. Localization and activity of lysyl oxidase within nuclei of fibrogenic cells. Proc. Nat. Acad. Sci. 94: 12817-12822, 1997.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

46944 MW

Observed Molecular Weight

31 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Protein-lysine 6-oxidase

Subcellular Location

Secreted, extracellular space.

Protein Name

Protein-lysine 6-oxidase

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.