Anti-LOXL1 Antibody Picoband®

About this product

Boster Bio Anti-LOXL1 Antibody Picoband® catalog # PB9719. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9719

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Lysyl oxidase homolog 1, also known as?LOXL1, is an?enzyme?which in humans is encoded by the?LOXL1?gene. This gene encodes a member of the?lysyl oxidase?gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in?collagens?and?elastin. A highly conserved amino acid sequence at the C-terminus?end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The?N-terminus?is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and?chemotaxis?to each member of the family.

Synonyms

Lysyl oxidase homolog 1;1.4.3.-; Lysyl oxidase-like protein 1; LOL; LOXL1; LOXL

Gene Name

LOXL1

Gene ID

4016

UniProt

Q08397

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human LOXL1, different from the related mouse sequence by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina. .

Applications

IHC, WB

Field of Research

Amino Acid Metabolism, Amino Acids, Cancer, Cell Biology, Metabolic Signaling Pathways, Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Active on elastin and collagen substrates. .

References & Citations

1. Kenyon K, Modi WS, Contente S, Friedman RM (September 1993) . A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25. The Journal of Biological Chemistry 268 (25) : 18435–7. 2. Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA, Yanagisawa H, Zuo J, Li T (Feb 2004) . Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat. Genet. (United States) 36 (2) : 178–82. 3. Entrez Gene: LOXL1 lysyl oxidase-like 1.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

63110 MW

Observed Molecular Weight

63 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Lysyl oxidase homolog 1

Subcellular Location

Secreted, extracellular space .

Protein Name

Lysyl oxidase homolog 1

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.