Anti-Pax2 Antibody Picoband®

About this product

Boster Bio Anti-Pax2 Antibody Picoband® catalog # PB9734. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9734

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Paired box gene 2, also known as PAX2, is a protein which in humans is encoded by the PAX2 gene. This gene is mapped to 10q24. PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.

Synonyms

Paired box protein Pax-2; PAX2

Gene Name

PAX2

Gene ID

5076

UniProt

Q02962

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Pax2, identical to the related mouse sequence.

Clonality

Polyclonal

Tissue Specificity

Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.

Applications

IHC, WB

Field of Research

Cell Type Marker, Developmental Biology, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Neuroscience, Organogenesis, Transcription, Transcription Factors

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634) . Has a critical role in the development of the urogenital tract, the eyes, and the CNS. .

References & Citations

1. Entrez Gene: PAX2 paired box gene 2. 2. Pilz AJ, Povey S, Gruss P, Abbott CM (1993) . Mapping of the human homologs of the murine paired-box-containing genes. Mamm. Genome 4 (2) : 78–82. 3. Pfeffer, Peter L.; Bernhard Payter; Gerlinde Reim; Marina Pasca di Magliano; Meinrad Busslinger (2001) . The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by separate enhancers. Development (133) : 307–318.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

44706 MW

Observed Molecular Weight

45 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Paired box protein Pax-2

Subcellular Location

Nucleus.

Protein Name

Paired box protein Pax-2

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.