Anti-Neuroserpin/SERPINI1 Antibody Picoband®

About this product

Boster Bio Anti-Neuroserpin/SERPINI1 Antibody Picoband® catalog # PB9744. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9744

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene. This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Synonyms

Neuroserpin; Peptidase inhibitor 12; PI-12; Serpin I1; SERPINI1; PI12

Gene Name

SERPINI1

Gene ID

5274

UniProt

Q99574

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Neuroserpin, different from the related mouse sequence by two amino acids, and from the related rat sequence by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in the brain.

Applications

WB

Field of Research

Axonal Guidance Proteins, Cell Type Marker, Growth and Development, Neurodegenerative Disease, Neurology Process, Neuron Marker, Neuroscience

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.

References & Citations

1. Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1. 2. Yepes M, Lawrence DA (2004) . Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system.. Thromb. Haemost. 91 (3) : 457–64.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

46427 MW

Observed Molecular Weight

46 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Neuroserpin

Subcellular Location

Secreted.

Protein Name

Neuroserpin

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.