Anti-Prealbumin/TTR Antibody Picoband®

About this product

Boster Bio Anti-Prealbumin/TTR Antibody Picoband® catalog # PB9749. Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9749

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Transthyretin (TTR) is also known as prealbumin. It is mapped to chromosome region 18q11.2-q12.1. This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease.

Synonyms

Transthyretin; ATTR; Prealbumin; TBPA; TTR; PALB

Gene Name

TTR

Gene ID

7276

UniProt

P02766

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Prealbumin recombinant protein (Position: G21-E147) . Human Prealbumin shares 81% and 83.3% amino acid (aa) sequence identity with mouse and rat Prealbumin, respectively.

Clonality

Polyclonal

Tissue Specificity

Detected in serum and cerebrospinal fluid (at protein level) . Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver. .

Applications

ELISA (Cap), IHC, WB

Field of Research

Alzheimer's Disease, Cardiovascular, Neurodegenerative Disease, Neurology Process, Neuroscience, Serum Proteins

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. .

References & Citations

1. Benson, M. D., Dwulet, F. E. Identification of carriers of a variant plasma prealbumin (transthyretin) associated with familial amyloidotic polyneuropathy type I. J. Clin. Invest. 75: 71-75, 1985. 2. Sparkes, R. S., Sasaki, H., Mohandas, T., Yoshioka, K., Klisak, I., Sakaki, Y., Heinzmann, C., Simon, M. I. Assignment of the prealbumin (PALB) gene (familial amyloidotic polyneuropathy) to human chromosome region 18q11.2-q12.1. Hum. Genet. 75: 151-154, 1987.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

15887 MW

Observed Molecular Weight

14 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Transthyretin

Subcellular Location

Secreted. Cytoplasm.

Protein Name

Transthyretin

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.