Anti-Prealbumin/TTR Antibody Picoband®

About this product

Boster Bio Anti-Prealbumin/TTR Antibody Picoband® catalog # PB9750. Tested in IF, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9750

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Transthyretin (TTR) is also known as prealbumin. It is mapped to chromosome region 18q11.2-q12.1. This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease.

Synonyms

Transthyretin; Prealbumin; TBPA; Ttr; Tt

Gene Name

Ttr

Gene ID

24856

UniProt

P02767

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived rat Prealbumin recombinant protein (Position: G21-N147) . Rat Prealbumin shares 94.5% amino acid (aa) sequence identity with mouse Prealbumin.

Clonality

Polyclonal

Tissue Specificity

Detected in serum and cerebrospinal fluid (at protein level) . Highly expressed in the choroid plexus. Detected at lower levels in the liver. .

Applications

IF, IHC, WB

Field of Research

Alzheimer's Disease, Cardiovascular, Neurodegenerative Disease, Neurology Process, Neuroscience, Serum Proteins

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. .

References & Citations

1. Benson, M. D., Dwulet, F. E. Identification of carriers of a variant plasma prealbumin (transthyretin) associated with familial amyloidotic polyneuropathy type I. J. Clin. Invest. 75: 71-75, 1985. 2. Sparkes, R. S., Sasaki, H., Mohandas, T., Yoshioka, K., Klisak, I., Sakaki, Y., Heinzmann, C., Simon, M. I. Assignment of the prealbumin (PALB) gene (familial amyloidotic polyneuropathy) to human chromosome region 18q11.2-q12.1. Hum. Genet. 75: 151-154, 1987.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

15720 MW

Observed Molecular Weight

16 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Transthyretin

Subcellular Location

Secreted .

Protein Name

Transthyretin

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.