Anti-PIGR Antibody Picoband®

About this product

Boster Bio Anti-PIGR Antibody Picoband® catalog # PB9776. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9776

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Polymeric immunoglobulin receptor is a protein that in humans is encoded by the PIGR gene. It is a Fc receptor which facilitates the secretion of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M. This gene is mapped to 1q31-q41. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.

Synonyms

Polymeric immunoglobulin receptor; PIgR; Poly-Ig receptor; Hepatocellular carcinoma-associated protein TB6; Secretory component; PIGR

Gene Name

PIGR

Gene ID

5284

UniProt

P01833

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human PIGR, different from the related rat sequence by eighteen amino acids.

Clonality

Polyclonal

Tissue Specificity

Widely expressed, with highest expression in liver and kidney.

Applications

Flow Cytometry, WB

Field of Research

Immunoglobulins, Immunology, Receptors

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

References & Citations

1. Entrez Gene: PIGR polymeric immunoglobulin receptor. 2. Hood L, Kronenberg M, Hunkapiller T (Feb 1985) . T cell antigen receptors and the immunoglobulin supergene family. Cell 40 (2) : 225–9. 3. Kaetzel CS (Aug 2005) . The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces. Immunological Reviews 206: 83–99.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

83284 MW

Observed Molecular Weight

83 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Polymeric immunoglobulin receptor

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Name

Polymeric immunoglobulin receptor

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.