Anti-LAR/PTPRF Antibody Picoband®

About this product

Boster Bio Anti-LAR/PTPRF Antibody Picoband® catalog # PB9786. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9786

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Receptor-type tyrosine-protein phosphatase F is an enzyme that in humans is encoded by the PTPRF gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Synonyms

Receptor-type tyrosine-protein phosphatase F;3.1.3.48; Leukocyte common antigen related; LAR; PTPRF; LAR

Gene Name

PTPRF

Gene ID

5792

UniProt

P10586

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human LAR, different from the related mouse and rat sequences by four amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in breast, placenta, kidney, liver and pancreas. .

Applications

IHC, WB

Field of Research

Neurology Process, Neuron Marker, Neuroscience, Protein Phosphorylation, Signal Transduction, Synapse Marker, Tyrosine Phosphatases

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.

References & Citations

1. Entrez Gene: PTPRF protein tyrosine phosphatase, receptor type, F. 2. Harder KW, Saw J, Miki N, Jirik F (Nov 1995) . Coexisting amplifications of the chromosome 1p32 genes (PTPRF and MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a small cell lung cancer line.Genomics 27 (3) : 552–3.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

212879 MW

Observed Molecular Weight

240 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Receptor-type tyrosine-protein phosphatase F

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

Receptor-type tyrosine-protein phosphatase F

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.