Anti-UNC5C Antibody Picoband®

About this product

Boster Bio Anti-UNC5C Antibody Picoband® catalog # PB9841. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9841

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene. This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediates the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig) -like domains and 2 type I thrombospondin motifs in the extracellular region.

Synonyms

Netrin receptor UNC5C; Protein unc-5 homolog 3; Protein unc-5 homolog C; UNC5C; UNC5H3

Gene Name

UNC5C

Gene ID

8633

UniProt

O95185

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human UNC5C, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung. .

Applications

WB, Flow Cytometry

Field of Research

Axonal Guidance Proteins, Developmental Biology, Growth and Development, Nervous System Development, Neurogenesis, Neurology Process, Neuroscience, Organogenesis

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. .

References & Citations

1. Entrez Gene: UNC5C unc-5 homolog C (C. elegans) . 2. Ackerman SL, Knowles BB (Dec 1998) . Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23.Genomics 52 (2) : 205–8. 3. Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M (May 1997) . Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386 (6627) : 833–8.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

103146 MW

Observed Molecular Weight

115 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Netrin receptor UNC5C

Subcellular Location

Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse, synaptosome .

Protein Name

Netrin receptor UNC5C

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.