Anti-SULT2B1 Antibody Picoband®

About this product

Boster Bio Anti-SULT2B1 Antibody Picoband® catalog # PB9822. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9822

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. And this gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described.

Synonyms

Sulfotransferase family cytosolic 2B member 1; ST2B1; Sulfotransferase 2B1;2.8.2.2; Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2; SULT2B1; HSST2

Gene Name

SULT2B1

Gene ID

6820

UniProt

O00204

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human SULT2B1, different from the related mouse sequence by six amino acids, and from the related rat sequence by five amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung. .

Applications

Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Cancer, Cardiovascular, Cholesterol Metabolism, Drug Metabolism, Growth Factors/Hormones, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. .

References & Citations

1. Entrez Gene: SULT2B1 sulfotransferase family, cytosolic, 2B, member 1. 2. Geese WJ, Raftogianis RB (2001) . Biochemical characterization and tissue distribution of human SULT2B1. Biochem. Biophys. Res. Commun. 288 (1) : 280–9. 3. Her C, Wood TC, Eichler EE, Mohrenweiser HW, Ramagli LS, Siciliano MJ, Weinshilboum RM (Dec 1998) . Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene. Genomics 53 (3) : 284–95.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

41308 MW

Observed Molecular Weight

48 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Sulfotransferase family cytosolic 2B member 1

Subcellular Location

Cytoplasm. Microsome. Nucleus. Phosphorylation of Ser-348 is required for translocation to the nucleus.

Protein Name

Sulfotransferase family cytosolic 2B member 1

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.