Anti-Ceruloplasmin/CP Antibody Picoband®

About this product

Boster Bio Anti-Ceruloplasmin/CP Antibody Picoband® catalog # PB9852. Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9852

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Ceruloplasmin  (or  caeruloplasmin) is a  ferroxidase  enzyme  that in humans is encoded by the  CP  gene. It is mapped to 3q23-q25. The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe (II) transferrin to Fe (III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

Synonyms

Ceruloplasmin;1.16.3.1; Ferroxidase; CP

Gene Name

CP

Gene ID

1356

UniProt

P00450

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Ceruloplasmin recombinant protein (Position: K20-M259) . Human Ceruloplasmin shares 80.8% and 79.6% amino acid (aa) sequence identity with mouse and rat Ceruloplasmin, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed by the liver and secreted in plasma.

Applications

Flow Cytometry, WB

Field of Research

Signal Transduction, Stem Cells, Vasculature

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe (2+) to Fe (3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu (2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity) . .

References & Citations

1. Koschinsky ML, Funk WD, van Oost BA, MacGillivray RT (Jul 1986) .Complete cDNA sequence of human preceruloplasmin. Proceedings of the National Academy of Sciences of the United States of America 83 (14) : 5086–90. 2. Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (May 1987) . Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somatic Cell and Molecular Genetics 13 (3) : 285–92. 3. Takahashi N, Ortel TL, Putnam FW (Jan 1984) . Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule. Proceedings of the National Academy of Sciences of the United States of America 81 (2) : 390–4.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

122205 MW

Observed Molecular Weight

122 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Ceruloplasmin

Subcellular Location

Secreted. Colocalizes with GCP1 in secretory intracellular compartments. .

Protein Name

Ceruloplasmin

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.