Anti-Cathepsin K/CTSK Antibody Picoband®

About this product

Boster Bio Anti-Cathepsin K/CTSK Antibody Picoband® catalog # PB9856. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9856

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cathepsin K, abbreviated?CTSK, is an?enzyme?that in humans is encoded by the?CTSK?gene. It is mapped to 1q21. The protein encoded by this gene is a lysosomal?cysteine protease?involved in bone remodeling and resorption. And this protein, which is a member of the peptidase C1 protein family, is expressed predominantly in?osteoclasts. Additionally, the enzyme's ability to catabolize?elastin, ?collagen, and?gelatin?allow it to break down?bone?and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil inemphysema. Cathepsin K?inhibitors, such as?odanacatib, show great potential in the treatment of?osteoporosis. Cathepsin K is degraded by Cathepsin S, called Controlled Cathepsin Cannibalism.

Synonyms

Cathepsin K;3.4.22.38; Cathepsin O; Cathepsin O2; Cathepsin X; CTSK; CTSO, CTSO2

Gene Name

CTSK

Gene ID

1513

UniProt

P43235

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Cathepsin K recombinant protein (Position: A115-M329) . Human Cathepsin K shares 86.9% and 88.8% amino acid (aa) sequence identity with mouse and rat Cathepsin K, respectively.

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in osteoclasts (bones) .

Applications

IHC, WB

Field of Research

Angiogenesis, Atherosclerosis, Cancer, Cardiovascular, Cell Adhesion Proteins, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Neuroscience, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

References & Citations

1. Entrez Gene: CTSK cathepsin K. 2. Inaoka T, Bilbe G, Ishibashi O, Tezuka K, Kumegawa M, Kokubo T (January 1995) . Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone. Biochem. Biophys. Res. Commun. 206 (1) : 89–96. 3. Motyckova G, Fisher DE (2003) . Pycnodysostosis: role and regulation of cathepsin K in osteoclast function and human disease.. Curr. Mol. Med. 2 (5) : 407–21.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

36966 MW

Observed Molecular Weight

45 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Cathepsin K

Subcellular Location

Lysosome.

Protein Name

Cathepsin K

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.