Anti-CXCL2 Antibody Picoband®

About this product

Boster Bio Anti-CXCL2 Antibody Picoband® catalog # PB9857. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9857

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Chemokine (C-X-C motif) ligand 2  (CXCL2) is a small  cytokine  belonging to the CXC  chemokine  family that is also called  macrophage inflammatory protein 2-alpha  (MIP2-alpha),   Growth-regulated protein beta  (Gro-beta) and  Gro oncogene-2 (Gro-2) . CXCL2 is 90% identical in  amino acid  sequence as a related chemokine,   CXCL1. This chemokine is secreted by monocytes  and  macrophages  and is  chemotactic  for  polymorphonuclear leukocytes  and  hematopoietic stem cells. The gene for CXCL2 is located on human  chromosome 4  in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface  chemokine receptor  called  CXCR2.

Synonyms

C-X-C motif chemokine 2; Growth-regulated protein beta; Gro-beta; Macrophage inflammatory protein 2-alpha; MIP2-alpha; GRO-beta (5-73) ; GRO-beta-T; Hematopoietic synergistic factor; HSF; SB-251353; CXCL2; GRO2, GROB, MIP2A, SCYB2

Gene Name

CXCL2

Gene ID

2920

UniProt

P19875

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human CXCL2 recombinant protein (Position: T39-N107) . Human CXCL2 shares 66.7% and 62.3% amino acid (aa) sequence identity with mouse and rat CXCL2, respectively.

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in osteoclasts (bones) .

Applications

ELISA, WB

Field of Research

Chemokines, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta (5-73) shows a highly enhanced hematopoietic activity. .

References & Citations

1. Iida N., Grotendorst G.R. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol. Cell. Biol. 10:5596-5599, 1990. 2. Pelus LM, Fukuda S. Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties. Exp Hematol. 2006 Aug;34 (8) :1010-20. 3. Wolpe, S. D., Sherry, B., Juers, D., Davatelis, G., Yurt, R. W., Cerami, A. Identification and characterization of macrophage inflammatory protein 2. Proc. Nat. Acad. Sci. 86: 612-616, 1989.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

11389 MW

Observed Molecular Weight

11 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

C-X-C motif chemokine 2

Subcellular Location

Secreted.

Protein Name

C-X-C motif chemokine 2

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.