Anti-CXCL2 Antibody Picoband®

About this product

Boster Bio Anti-CXCL2 Antibody Picoband® catalog # PB9858. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9858

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Chemokine (C-X-C motif) ligand 2  (CXCL2) is a small  cytokine  belonging to the CXC  chemokine  family that is also called  macrophage inflammatory protein 2-alpha  (MIP2-alpha),   Growth-regulated protein beta  (Gro-beta) and  Gro oncogene-2 (Gro-2) . CXCL2 is 90% identical in  amino acid  sequence as a related chemokine,   CXCL1. This chemokine is secreted by monocytes  and  macrophages  and is  chemotactic  for  polymorphonuclear leukocytes  and  hematopoietic stem cells. The gene for CXCL2 is located on human  chromosome 4  in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface  chemokine receptor  called  CXCR2.

Synonyms

C-X-C motif chemokine 2; Cytokine-induced neutrophil chemoattractant 3; CINC-3; Macrophage inflammatory protein 2; MIP2; Cxcl2; Cinc3, Mip-2, Mip2, Scyb2

Gene Name

Cxcl2

Gene ID

114105

UniProt

P30348

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived rat CXCL2 recombinant protein (Position: S32-N100) . Rat CXCL2 shares 62.3% and 88.4% amino acid (aa) sequence identity with huamn and mouse CXCL2, respectively.

Clonality

Polyclonal

Tissue Specificity

At least expressed in the lung and trachea.

Applications

ELISA, WB

Field of Research

Chemokines, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation.

References & Citations

1. Iida N., Grotendorst G.R. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol. Cell. Biol. 10:5596-5599, 1990. 2. Pelus LM, Fukuda S. Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties. Exp Hematol. 2006 Aug;34 (8) :1010-20. 3. Wolpe, S. D., Sherry, B., Juers, D., Davatelis, G., Yurt, R. W., Cerami, A. Identification and characterization of macrophage inflammatory protein 2. Proc. Nat. Acad. Sci. 86: 612-616, 1989.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

10783 MW

Observed Molecular Weight

11 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

C-X-C motif chemokine 2

Subcellular Location

Secreted.

Protein Name

C-X-C motif chemokine 2

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.