Anti-FCGRT Antibody Picoband®

About this product

Boster Bio Anti-FCGRT Antibody Picoband® catalog # PB9867. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9867

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

IgG receptor FcRn large subunit p51?is a?protein?that in humans is encoded by the?FCGRT?gene. This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation.?In addition, it is postulated that long-range cis inactivation of the?FCGRT?gene is responsible for hypercatabolism of IgG in myotonic dystrophy. The?FCGRT?gene is closely situated to the DMPK gene, which is mutant in DM.?

Synonyms

IgG receptor FcRn large subunit p51; FcRn; IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor; Fcgrt; Fcrn

Gene Name

Fcgrt

Gene ID

14132

UniProt

Q61559

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse FCGRT recombinant protein (Position: Q54-D291) . Mouse FCGRT shares 70.2% and 92.4% amino acid (aa) sequence identity with human and rat FCGRT, respectively.

Clonality

Polyclonal

Tissue Specificity

Intestinal epithelium of suckling rodents. Expressed in neonatal intestine and fetal yolk sac.

Applications

ELISA, IHC, WB

Field of Research

Adaptive Immunity, Class I, Immunoglobulins, Immunology, Receptors

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids.

References & Citations

1. Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, Anderson CL (February 2003) . The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J. Exp. Med. 197 (3) : 315–22. 2. Junghans, R. P., Ebralidze, A., Tiwari, B. Does (CUG) n repeat in DMPK mRNA 'paint' chromosome 19 to suppress distant genes to create the diverse phenotype of myotonic dystrophy? A new hypothesis of long-range cis autosomal inactivation. Neurogenetics 3: 59-67, 2001. 3. Kandil E, Egashira M, Miyoshi O, Niikawa N, Ishibashi T, Kasahara M, Miyosi O (July 1996) . The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3. Cytogenet. Cell Genet. 73 (1-2) : 97–8.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

40093 MW

Observed Molecular Weight

50 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

IgG receptor FcRn large subunit p51

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Name

IgG receptor FcRn large subunit p51

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.