Anti-FGF23 Antibody Picoband®

About this product

Boster Bio Anti-FGF23 Antibody Picoband® catalog # PB9868. Tested in WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9868

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fibroblast growth factor 23?or?FGF23?is a?protein?that in humans is encoded by the?FGF23?gene. This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR) . Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC) .

Synonyms

Fibroblast growth factor 23; FGF-23; Fgf23

Gene Name

Fgf23

Gene ID

64654

UniProt

Q9EPC2

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse FGF23 recombinant protein (Position: R48-V251) . Mouse FGF23 shares 71.1% and 94.6% amino acid (aa) sequence identity with human and rat FGF23, respectively.

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in the brain and thymus at low levels. In brain; preferentially expressed in the ventrolateral thalamic nucleus.

Applications

WB

Field of Research

Cancer, Cytoskeleton/ECM, Developmental Biology, Extracellular Matrix, Growth Factors, Growth Factors/Hormones, Lineage Markers, Lineage Specification, Signal Transduction, Stem Cells, Structures

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Regulator of phosphate homeostasis (By similarity) . Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity) . Acts ly on the parathyroid to decrease PTH secretion (By similarity) . Regulator of vitamin-D metabolism (By similarity) . Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity) . Upregulates EGR1 expression in the presence of KL. .

References & Citations

1. Entrez Gene: FGF23 fibroblast growth factor 23. 2. Fukumoto S (2008) . Physiological regulation and disorders of phosphate metabolism--pivotal role of fibroblast growth factor 23. Intern. Med. 47 (5) : 337–43. 3. Yamashita T, Yoshioka M, Itoh N (October 2000) . Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem. Biophys. Res. Commun.277 (2) : 494–8.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

27758 MW

Observed Molecular Weight

34 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Fibroblast growth factor 23

Subcellular Location

Secreted . Secretion is dependent on O-glycosylation. .

Protein Name

Fibroblast growth factor 23

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.