Anti-EPCR/CD201/PROCR Antibody Picoband®

About this product

Boster Bio Anti-EPCR/CD201/PROCR Antibody Picoband® catalog # PB9880. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9880

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor), is a protein that in humans is encoded by the PROCR gene. It has also recently been designated CD201 (cluster of differentiation 201) . The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. And it is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer.

Synonyms

Endothelial protein C receptor; Activated protein C receptor; APC receptor; Endothelial cell protein C receptor; CD201; PROCR; EPCR

Gene Name

PROCR

Gene ID

10544

UniProt

Q9UNN8

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human EPCR/CD201 recombinant protein (Position: S18-S210) . Human EPCR/CD201 shares 65.5% and 65.6% amino acid (aa) sequence identity with mouse and rat EPCR/CD201, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

Applications

ELISA, WB

Field of Research

Cardiovascular, Hematopoietic Progenitors, Stem Cells, Vasculature

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

References & Citations

1. Entrez Gene: PROCR protein C receptor, endothelial (EPCR) . 2. Fukudome K, Esmon CT (Nov 1994) . Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem 269 (42) : 26486–91. 3. Rothbarth K, Dabaghian AR, Stammer H, Werner D (Oct 1999) . One single mRNA encodes the centrosomal protein CCD41 and the endothelial cell protein C receptor (EPCR) . FEBS Lett 458 (1) : 77–80.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

26671 MW

Observed Molecular Weight

46 kDa, 52 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Endothelial protein C receptor

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

Endothelial protein C receptor

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.