Anti-Ribonuclease Inhibitor/RNH1 Antibody Picoband®

About this product

Boster Bio Anti-Ribonuclease Inhibitor/RNH1 Antibody Picoband® catalog # PB9885. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9885

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Ribonuclease inhibitor is an enzyme that in humans is encoded by the RNH1 gene. Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular Rnases. In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin. Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.

Synonyms

Ribonuclease inhibitor; Placental ribonuclease inhibitor; Placental RNase inhibitor; Ribonuclease/angiogenin inhibitor 1; RAI; RNH1; PRI, RNH

Gene Name

RNH1

Gene ID

6050

UniProt

P13489

Host

Rabbit

Reactivity

Human, Monkey, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human RNH1, different from the related mouse sequence by five amino acids, and from the related rat sequence by four amino acids.

Clonality

Polyclonal

Tissue Specificity

Widely expressed; high expression found in skeletal muscle. .

Applications

Flow Cytometry, IHC, ICC, WB

Field of Research

Angiogenesis, Cardiovascular, DNA/RNA, Epigenetics and Nuclear Signaling, RNA Processing

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. .

References & Citations

1. Entrez Gene: RNH1 ribonuclease/angiogenin inhibitor 1. 2. Weremowicz S, Fox EA, Morton CC, Vallee BL (1991) . The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5.. Genomics 8 (4) : 717–21. 3. Zneimer SM, Crawford D, Schneider NR, Beutler B (1991) . Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization.. Genomics 8 (1) : 175–8.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

49973 MW

Observed Molecular Weight

50 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Ribonuclease inhibitor

Subcellular Location

Cytoplasm.

Protein Name

Ribonuclease inhibitor

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.