Anti-TCF7L1 Antibody Picoband®

About this product

Boster Bio Anti-TCF7L1 Antibody Picoband® catalog # PB9897. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9897

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Transcription factor 7-like 1 (T-cell specific, HMG-box), also known as TCF7L1, is a human gene. This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.

Synonyms

Transcription factor 7-like 1; HMG box transcription factor 3; TCF-3; TCF7L1; TCF3

Gene Name

TCF7L1

Gene ID

83439

UniProt

Q9HCS4

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human TCF7L1, different from the related mouse sequence by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium. .

Applications

IHC, WB

Field of Research

Chromatin Binding Proteins, DNA/RNA Binding, Domain Families, Epigenetics and Nuclear Signaling, Nuclear, Signaling Pathways, Stem Cells, Transcription, Transcription Factors

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity) . Down-regulates NQO1, leading to increased mitomycin c resistance. .

References & Citations

1. Entrez Gene: transcription factor 7-like 1 (T-cell specific, HMG-box) . 2. Castrop, J., van Norren, K., Clevers, H. A gene family of HMG-box transcription factors with homology to TCF-1. Nucleic Acids Res. 20: 611 only, 1992. 3. Sagara, N., Katoh, M. Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation. Cancer Res. 60: 5959-5962, 2000.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

62631 MW

Observed Molecular Weight

63 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Transcription factor 7-like 1

Subcellular Location

Nucleus.

Protein Name

Transcription factor 7-like 1

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.