Anti-CD134/OX40/TNFRSF4 Antibody Picoband®

About this product

Boster Bio Anti-CD134/OX40/TNFRSF4 Antibody Picoband® catalog # PB9898. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9898

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tumor necrosis factor receptor superfamily, member 4, also known as ACT35 or CD134, is a cell surface glycoprotein that was discovered through the production of a monoclonal antibody raised against the HUT-102 cell line. It belongs to the tumor necrosis factor receptor superfamily. CD134 was mapped to 1p36 by fluorescence in situ hybridization. CD134 is the primary receptor for feline immunodeficiency virus. And CD134 expression can promote viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Stimulating the receptor can improve the response to a powerful virus vector and may be useful in vaccine development.

Synonyms

Tumor necrosis factor receptor superfamily member 4; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD134; TNFRSF4; TXGP1L

Gene Name

TNFRSF4

Gene ID

7293

UniProt

P43489

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human CD134/OX40, different from the related mouse sequence by ten amino acids.

Clonality

Polyclonal

Applications

Flow Cytometry, IHC, ICC, WB

Field of Research

Adaptive Immunity, Autoimmune, B Cells, Cytokines, Hematopoietic Progenitors, Immune System Diseases, Immunology, Innate Immunity, Lymphoid, Stem Cells, T Cells, T Lymphocytic Lineage, TNF Superfamily

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. .

References & Citations

1. Bansal-Pakala, P., Jember, A. G.-H., Croft, M. Signaling through OX40 (CD134) breaks peripheral T-cell tolerance. Nature Med. 7: 907-912, 2001. 2. Humphreys, I. R., Walzl, G., Edwards, L., Rae, A., Hill, S., Hussell, T. A critical role for OX40 in T cell-mediated immunopathology during lung viral infection. J. Exp. Med. 198: 1237-1242, 2003. 3. Jember, A. G.-H., Zuberi, R., Liu, F.-T., Croft, M. Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40. J. Exp. Med. 193: 387-392, 2001. 4. Shimojima, M., Miyazawa, T., Ikeda, Y., McMonagle, E. L., Haining, H., Akashi, H., Takeuchi, Y., Hosie, M. J., Willett, B. J. Use of CD134 as a primary receptor by the feline immunodeficiency virus. Science 303: 1192-1195, 2004.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

29341 MW

Observed Molecular Weight

50 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Tumor necrosis factor receptor superfamily member 4

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

Tumor necrosis factor receptor superfamily member 4

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.